Custom Peptides
Cayman Chemical IsomItraphylIn 10mg
An alkaloid with anticancer activity; antagonist of Drosophila ecdysteroid receptors in a reporter assay using Drosophila BII cells (EC50 = 160 µM); reduces the proliferation of, and induces apoptosis in, CCRF CEM C7H2 leukemia cells at 50 or 100 µM
Cayman Chemical 18-methyl EIcosnoIc AcId 10mg
A main component of the outer layer of the epicuticle of human hair that is used as an additive to hair cosmetics due to its desirable conditioning effects
Cayman Chemical EIcosapentaenoIc ACDpRoxI 10mg
An ω-3 fatty acid abundantly available in marine organisms; a poor substrate for COX-1 that is oxygenated by COX-1 and COX-2 at rates of about 5% and 30%, respectively, compared to arachidonic acid; has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases
Cayman Chemical BarnIdIpInhydrochlorIde 10mg
A calcium channel blocker that selectively antagonizes cardiovascular calcium channels; demonstrates antihypertensive activity by reducing peripheral vascular resistance; decreases blood pressure in spontaneously hypertensive rats
Cayman Chemical ZamIfenacInfumarate 10mg
An antagonist of M3 muscarinic acetylcholine receptors (Ki = 10 nM for the human receptor); selective for M3 over M1, M2, M4, and M5 receptors in radioligand binding assays (Kis = 55, 153, 68, and 34 nM, respectively); inhibits cholecystokinin-induced small bowel motility (ED50 = 0.9 mg/kg) but does not increase heart rate (ED150 = 80.0 mg/kg) in dogs
Cayman Chemical PolIumosIde 10mg
A phenylethanoid glycoside; scavenges DPPH and ABTS radicals (IC50s = 10.9 and 19.9 µM), as well as inhibits the activity of PKCα (IC50 = 24.4 µM), in cell-free assays); reduces LPS-induced production of TNF-α and IL-6 in RAW 264.7 cells from 12.5-100 µM; decreases glutamate-induced cytotoxicity in primary rat cortical neurons at 0.1, 1, or 10 µM
Cayman Chemical LevonrdefrIn 10mg
A vasoconstrictor; (–)-enantiomer of nordefrin; rapidly increases blood pressure and heart rate in anesthetized dogs (1-5 UG/kg); in combination with mepivacaine, increases systolic arterial blood pressure in anesthetized dogs (0.514 and 1.542 mg/kg)
Cayman Chemical 5methyl2HOBAhydrochlorId 10mg
An isoketal scavenger; reduces angiotensin II-induced increases in systolic blood pressure in mice
Cayman Chemical ProstaglndIn F2tromethamI 10mg
A derivative of PGF2β with increased water solubility
Cayman Chemical -PInoresInol 10mg
A lignan with diverse biological activities; an inhibitor of α-glucosidase and maltase (IC50s = 492 and 34.3 µM in Baker’s yeast and rat small intestine, respectively); scavenges ABTS, but not DPPH, radicals in cell-free assays (IC50s = 13.43 and >200 UG/ml, respectively); cytotoxic to A549, HepG2, and MCF-7, but not U251 and Bcap-37, cells (IC50s = 29.35, 62.35, 75.32, >80, and >80 µM, respectively); prevents cell death induced by glutamate in HT22 cells (EC50 = 6.96 µM) and inhibits LPS-induced nitric oxide production in RAW 264.7 cells (IC50 = 7.89 µM)
Cayman Chemical 6 5H-PhenthrIdInon 10mg
An inhibitor of PARP1 and 2 (EC50s = 10.2 and 36.3 μM, respectively, in yeast cells expressing the human enzymes); decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells at 50 μM; reduces NF-κB-induced transcription of the genes encoding TNF-α, IL-2, and IFN-γ in rat lymphocytes; reduces spinal cord expression of iNOS, IL-1β, TNF-α, IL-2, and IFN-γ and reduces disease score in a rat model of EAE at 60 mg/kg; decreases serum levels of lactate dehydrogenase as well as hepatic lipid peroxidation, oxidative DNA damage, and PARP levels in a mouse model of carbon tetrachloride-induced hepatotoxicity at 10 mg/kg
Cayman Chemical A8SGLP1trIfluoroACTAte sa 10mg
A peptide agonist of GLP-1R and a derivative of GLP-1 (7-36) amide; induces cAMP accumulation in RIN T3 cells (EC50 = 15 nM); reduces blood levels of glucose in the OGTT, serum levels of Il-1β, Il-6, and Tnf-α, and fat mass in diabetic db/db mice in lyophilized L. lactis, p.o.
Cayman Chemical BenzoylaconIn 10mg
An aconitine-type diterpenoid alkaloid that has been found in Aconitum species; increases protein levels of the efflux transporters P-glycoprotein, MRP2, and BCRP in LS174T cells in a concentration-dependent manner; increases the protein levels of P-glycoprotein in Caco-2 cells and the PXR in both Caco-2 and LS174T cells at 50 μM; reduces the cytotoxic effects of the P-glycoprotein substrates vincristine and doxorubicin in Caco-2 cells at 50 μM; increases protein levels of Nrf2, MRP2, and BCRP in the jejunum, ileum, and colon in mice at 0.6 mg/kg; increases survival of mice injected with a lethal dose of the neurotoxin aconitine (ED50 = 15 mg/kg, i.p.)